The Science

Mitochondrial Biology and Chronic Disease

Mitochondria play essential roles in cellular energy production, metabolic regulation, and stress adaptation. Under sustained stress, mitochondrial behavior can shift in ways that influence cellular signaling, tissue remodeling, inflammatory responses, and disease progression.

These mitochondrial-associated processes are increasingly linked to chronic diseases including cardiomyopathy, polycystic kidney and liver disease (PKD/PLD), fibrosis, inflammatory disorders, and cancer.

ICM Therapeutics is advancing a mitochondrial therapeutic platform centered on novel small-molecule approaches designed to modulate disease-associated mitochondrial and cellular pathways.

Our translational and clinical programs are currently focused on infectious cardiomyopathy, PKD/PLD, and oncology.